BIO⁴

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  • BIO⁴

BIO⁴
Category: Biomaterials

A viable bone matrix containing endogenous bone forming cells (including mesenchymal stem cells, osteoprogenitor cells, and osteoblasts) as well as osteoinductive and angiogenic growth factors

Description

BIO4 possesses all four characteristics involved in bone repair and regeneration: osteoconductive, osteoinductive, osteogenic, and angiogenic.1-3 It is an alternative to autograft that minimizes the potential for harvest site comorbidities. BIO4:
 
  • Is lot tested for the presence of VEGF (vascular endothelial growth factor)
  • Is lot tested for ≥ 70% cell viability post-thaw
  • Contains ≥ 600,000 cells/cc (endogenous bone forming cells including mesenchymal stem cells)
  • Is ready to use out of the package; no decanting is required, and thaws in 15 minutes
  • Has differentiated handling compared to competition
  • Is non-immunogenic
  • Is available in 1, 2.5, 5 and 10cc sizes
 
BIO4 is manufactured by Osiris Therapeutics, Inc. 
 
References:
  1. Data on file at Osiris Therapeutics, Inc. 
  2. Roberts and Rosenbaum, “Bone grafts, bone substitutes and orthobiologics,” Organogenesis (2012).
  3. Bourke et al., “Vascular Endothelial Growth Factor (VEGF) in Human Peristeum - Normal Expression and Response to Fracture,” Journal of Bone & Joint Surgery, British Volume (2003).
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